Levallorphan

Levallorphan Uses, Dosage, Side Effects, Food Interaction and all others data.

An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Levallorphan
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Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Levallorphan
Generic	Levallorphan
Levallorphan Other Names	Levallofano, Levallorphan, Lévallorphane, Levallorphanum, Levalorfano
Type
Formula	C₁₉H₂₅NO
Weight	Average: 283.4079 Monoisotopic: 283.193614427
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

How Levallorphan works

Levallorphan antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.