Levocabastinum
Levocabastinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Levocabastinum is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastinum was discovered at Janssen Pharmaceutica in 1979.
Levocabastinum is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis can be inhibited by levocabastine. Levocabastinum can also reduce symptoms of allergic rhinitis by preventing an increase in vascular permeability of nasal mucosa.
| Trade Name | Levocabastinum |
| Generic | Levocabastine |
| Levocabastine Other Names | Levocabastina, Levocabastine, Levocabastinum |
| Type | |
| Formula | C26H29FN2O2 |
| Weight | Average: 420.528 Monoisotopic: 420.221306345 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Levocabastinum is a selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
Levocabastinum is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Conjunctivitis allergic
How Levocabastinum works
Levocabastinum is a potent, selective histamine H1-receptor antagonist. It works by competing with histamine for H1-receptor sites on effector cells. It thereby prevents, but does not reverse, responses mediated by histamine alone. Levocabastinum does not block histamine release but, rather, prevents histamine binding and activity. Levocabastinum also binds neurotensin 2 receptors and serves as a neurotensin agonist. This can induce some degree of analgesia.
Toxicity
Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.
Food Interaction
No interactions found.Elimination Route
After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.
Half Life
36 hours (after oral administration)
Innovators Monograph
You find simplified version here Levocabastinum
