Levorfanolo
Levorfanolo Uses, Dosage, Side Effects, Food Interaction and all others data.
A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.
Levorfanolo is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorfanolo is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorfanolo produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Trade Name | Levorfanolo |
Availability | Prescription only |
Generic | Levorphanol |
Levorphanol Other Names | Levorfanol, Levorfanolo, Lévorphanol, Levorphanol, Levorphanolum |
Related Drugs | Buprenex, aspirin, acetaminophen, tramadol, naproxen, Tylenol, oxycodone, diazepam, promethazine, Valium |
Type | |
Formula | C17H23NO |
Weight | Average: 257.3706 Monoisotopic: 257.177964363 |
Protein binding | 40% |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Levorfanolo is an opioid analgesic used to treat moderate to severe pain.
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.
Levorfanolo is also used to associated treatment for these conditions: Severe Pain, Moderate Pain
How Levorfanolo works
Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain.
Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Food Interaction
- Avoid alcohol.
- Take with or without food. Food does not significantly affect absorption.
Levorfanolo Alcohol interaction
[Moderate] GENERALLY AVOID:
Ethanol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics.
Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills.
In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.
Concomitant use of opioid analgesics with ethanol should be avoided.
Levorfanolo Drug Interaction
Major: lorazepam, lorazepam, suvorexant, suvorexant, meperidine, meperidine, cyclobenzaprine, cyclobenzaprine, clonazepam, clonazepam, pregabalin, pregabalin, oxycodone, oxycodoneModerate: duloxetine, duloxetineUnknown: acetaminophen, acetaminophen, cholecalciferol, cholecalciferol
Levorfanolo Disease Interaction
Major: impaired GI motility, infectious diarrhea, liver disease, prematurity, acute alcohol intoxication, drug dependence, gastrointestinal obstruction, hypotension, intracranial pressure, respiratory depressionModerate: adrenal insufficiency, biliary spasm, hypothyroidism, renal dysfunction, seizure disorders, urinary retention, arrhythmias
Volume of Distribution
- 10 to 13 L/kg
Elimination Route
Levorfanolo is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Half Life
11-16 hours
Clearance
- 0.78 to 1.1 L/kg/hr
Innovators Monograph
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