Lice Md
Lice Md Uses, Dosage, Side Effects, Food Interaction and all others data.
Lice Md (PBO) is an organic compound used as a component of pesticide formulations. It is used for the treatment of head, pubic (crab), and body lice. Lice Md is a synergist. It has no pesticidal activity of its own, but acts to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. Lice Md is a semisynthetic derivative of safrole.
Lice Md does not affect the mixed-function oxidase system in humans. In small trials in human volunteers, usual doses of piperonyl butoxide had no effect on humans.
| Trade Name | Lice Md |
| Generic | Piperonyl butoxide |
| Type | |
| Formula | C19H30O5 |
| Weight | Average: 338.4385 Monoisotopic: 338.20932407 |
| Protein binding | Piperonyl butoxide is minimally absorbed in humans. Protein binding has not been studied. |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Lice Md is a pesticide used as a potentiator ingredient in the treatment of pediculosis (head lice, body lice or crabs) to boost efficacy of treatment.
For the treatment of head, pubic (crab), and body lice.
Lice Md is also used to associated treatment for these conditions: Head Lice Infestation, Lice of the body, Lice of the pubic area
How Lice Md works
Lice Md is not a pesticide, but acts as a synergist to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. Lice Md inhibits the mixed-function oxidase (MFO) system of an insect. The MFO system is the insects natural defense system and causes the oxidative breakdown of insecticides. Thus, by inhibiting this system piperonyl butoxide promotes higher levels of insecticide and allows for lower doses to be used for a lethal effect.
Toxicity
The acute oral LD50 for rats is 4,570 to 12,800 mg/kg and 2,700 to 5,300 mg/kg for rabbits. It is low to very low in toxicity when ingested by mammals.
Food Interaction
No interactions found.Volume of Distribution
Lice Md is minimally absorbed in humans. Volume of distribution has not been studied.
Elimination Route
Lice Md is applied topically. In a study evaluating the 7-day urinary accumulation of piperonyl butoxide after topical application, it was found that approximately 2% of the dose was absorbed through the skin. The percutaneous absorption when applied to the scalp was found to be 8.3%.
Half Life
32 hours.
Clearance
Clearance of piperonyl butoxide has not been studied.
Elimination Route
In an absorption study in human volunteers, it was found that, if absorbed, piperonyl butoxide was eliminated in urine.
Innovators Monograph
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