Locorten

Locorten Uses, Dosage, Side Effects, Food Interaction and all others data.

Locorten is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Locorten pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Trade Name Locorten
Generic Flumethasone
Flumethasone Other Names Flumetasona, Flumétasone, Flumetasone, Flumetasonum, Flumethasone
Type
Formula C22H28F2O5
Weight Average: 410.458
Monoisotopic: 410.190480328
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Locorten
Locorten

Uses

Locorten is a corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions.

For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions

Locorten is also used to associated treatment for these conditions: Atopic Dermatitis (AD), Atopic Dermatitis (AD) of the external ear canal, Cradle Cap, Dermatitis, Dermatosis, Discoid Lupus Erythematosus (DLE), Infantile Eczema, Inflammatory Skin Disease, Intertrigo, Lichen Planus (LP), Neurodermatitis, Otitis Externa, Psoriasis Vulgaris (Plaque Psoriasis), Radiodermatitis, Solar erythema, Corticosteroid-responsive dermatoses, Intertriginous erythema of the anogenital, Otomycosis caused by Aspergillus niger, Resistant to other corticosteroids Dermatosis

How Locorten works

Locorten is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Locorten binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Toxicity

Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.

Food Interaction

No interactions found.

Elimination Route

Minimal if applied topically

Innovators Monograph

You find simplified version here Locorten

*** Taking medicines without doctor's advice can cause long-term problems.
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