Mafenide

Mafenide Uses, Dosage, Side Effects, Food Interaction and all others data.

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.

Trade Name Mafenide
Availability Prescription only
Generic Mafenide
Mafenide Other Names 4-Homosufanilamide, Bensulfamide, Mafenide, Maphenidum
Related Drugs lidocaine topical, vancomycin, gentamicin, tobramycin, Silvadene, Garamycin
Weight 85mg/g, 5%
Type Powder, For Topical Solution, Topical Cream, Topical Powder For Reconstitution
Formula C7H10N2O2S
Weight Average: 186.232
Monoisotopic: 186.046298264
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Mafenide
Mafenide

Uses

Mafenide is an antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Mafenide is also used to associated treatment for these conditions: Second Degree Burns, Third Degree Burns

How Mafenide works

The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.

Toxicity

Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur.

Food Interaction

No interactions found.

Mafenide Disease Interaction

Moderate: acid/base balance, hemolytic anemia/DIC

Elimination Route

Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.

Elimination Route

Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.

Innovators Monograph

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https://www.drugs.com/international/Mafenide.html
https://en.wikipedia.org/wiki/Mafenide
*** Taking medicines without doctor's advice can cause long-term problems.
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