Mecamylamine
Mecamylamine Uses, Dosage, Side Effects, Food Interaction and all others data.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers.
| Trade Name | Mecamylamine |
| Availability | Prescription only |
| Generic | Mecamylamine |
| Mecamylamine Other Names | Mecamylamine |
| Related Drugs | amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide |
| Weight | 2.5mg |
| Type | Oral tablet |
| Formula | C11H21N |
| Weight | Average: 167.2911 Monoisotopic: 167.167399677 |
| Protein binding | 40% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mecamylamine is a nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.
For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Mecamylamine is also used to associated treatment for these conditions: Severe Hypertension, Moderate Hypertension, Uncomplicated Malignant hypertension
How Mecamylamine works
Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
Food Interaction
- Avoid excessive or chronic alcohol consumption. The ingestion of alcohol may potentiate the actions of mecamylamine.
- Take after a meal. This slows mecamylamine absorption allowing for a gradual reduction in blood pressure. Take consistently at the same time in regard to meals.
Mecamylamine Drug Interaction
Unknown: amoxicillin / clavulanate, amoxicillin / clavulanate, glucose, glucose, fentanyl, fentanyl, acetaminophen, acetaminophen, tiotropium, tiotropium
Mecamylamine Disease Interaction
Major: cardiovascular dysfunction, cerebrovascular dysfunction, glaucoma, neurologic dysfunction, renal dysfunction, urinary retentionModerate: dehydration
Elimination Route
Mecamylamine is almost completely absorbed from the gastrointestinal tract
Elimination Route
Mecamylamine is excreted slowly in the urine in the unchanged form. The rate of its renal elimination is influenced markedly by urinary pH. Alkalinization of the urine reduces, and acidification promotes, renal excretion of mecamylamine. Mecamylamine crosses the blood-brain and placental barriers.
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