IV Injection Uses, Dosage, Side Effects and more

Mecobal 500 mcg/ml IM/IV Injection is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Attribute	Details
Trade Name	Mecobal 500 mcg/ml IM/IV Injection
Generic	Mecobalamin
Mecobalamin Other Names	Co-methylcobalamin, MeCbl, Mecobalamin, Mecobalamina, Mecobalaminum, Methyl vitamin B12, Methyl(III)cobalamin, Methylcobalamin
Weight	500 mcg/ml
Type	IM/IV Injection
Formula	C₆₃H₉₁CoN₁₃O₁₄P
Weight	Average: 1344.3823 Monoisotopic: 1343.587806391
Groups	Approved, Investigational
Therapeutic Class	Drugs for Megaloblastic Anemia
Manufacturer	General Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	January 7, 2025 at 1:49 am

Uses

Mecobal 500 mcg/ml IM/IV Injection is used for-

Peripheral Neuropathies
Diabetic Neuropathy
Verteberal Syndrome
Nerve Compression Syndrome
Multiple sclerosis
Amyotrophic lateral sclerosis
Parkinson’s disease
Alzheimer’s disease
Diabetic retinopathy
Entrapment neuropathy
Drug induced neuropathy
Megaloblastic anemia due to Vitamin B12 deficiency

Mecobal 500 mcg/ml IM/IV Injection is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation

Dosage

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobal 500 mcg/ml IM/IV Injection, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobal 500 mcg/ml IM/IV Injection, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobal 500 mcg/ml IM/IV Injection every one to three months as maintenance therapy

Side Effects

Generally Mecobal 500 mcg/ml IM/IV Injection is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobal 500 mcg/ml IM/IV Injection.

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Precaution

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Interaction

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Not recommended during pregnancy & lactation.

Contraindication

Hypersensitivity to any component of this product.

Special Warning

Use in children: Not recommended.

Storage Condition

Oral: Store at room temperature. Protect from moisture and light.

Parenteral: Store at room temperature. Do not expose to direct light.

Innovators Monograph

FAQ

What is Mecobal 500 mcg/ml IM/IV Injection used for?

Mecobal 500 mcg/ml IM/IV Injection is used to treat vitamin B12 deficiency.

How safe is Mecobal 500 mcg/ml IM/IV Injection?

Mecobal 500 mcg/ml IM/IV Injection is considered likely safe when used appropriately.

How does Mecobal 500 mcg/ml IM/IV Injection work?

Mecobal 500 mcg/ml IM/IV Injection works by functioning in the production of a compound called myelin, which covers and protect nerve fibers.

What are the common side effects of Mecobal 500 mcg/ml IM/IV Injection?

Common side effects of Mecobal 500 mcg/ml IM/IV Injection are include:

Nausea.
Vomiting.
Diarrhea.
Loss of appetite.
Headache.

Is Mecobal 500 mcg/ml IM/IV Injection safe during pregnancy?

Pregnancy There are no data available for Mecobal 500 mcg/ml IM/IV Injection to be used in pregnant women.

Is Mecobal 500 mcg/ml IM/IV Injection safe during breastfeeding?

There are no data available for Mecobal 500 mcg/ml IM/IV Injection to be used in lactating women.

Can I drink alcohol with Mecobal 500 mcg/ml IM/IV Injection?

No interactions were found between Alcohol and Mecobal 500 mcg/ml IM/IV Injection. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take Mecobal 500 mcg/ml IM/IV Injection daily?

The recommended dose is 500 mcg three times daily or 1500 mcg daily. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.

How much Mecobal 500 mcg/ml IM/IV Injection should I take?

The general recommendation for adults is 2.4 mcg. Older adults, as well as pregnant and breastfeeding women, require higher doses.

Should I take Mecobal 500 mcg/ml IM/IV Injection on an empty stomach?

It is a well-known medical fact that water-soluble vitamins are better absorbed on an empty stomach. So, the usual time of taking Mecobal 500 mcg/ml IM/IV Injection will be in the morning as the first dose, half an hour before lunch, and 2 hours post a meal.

How long does Mecobal 500 mcg/ml IM/IV Injection take to work?

With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. Mecobal 500 mcg/ml IM/IV Injection supplies have reached normal levels,Mecobal 500 mcg/ml IM/IV Injection injections will be required every one to three months to avoid the return of symptoms.

How long does Mecobal 500 mcg/ml IM/IV Injection supplements stay in my system?

Other studies have shown that Mecobal 500 mcg/ml IM/IV Injection has a half-life of around six days in the blood, which means that it would take six days before half of the administered amount is excreted from the body

Can Mecobal 500 mcg/ml IM/IV Injection damage my liver?

There is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.

What are the symptoms of high Mecobal 500 mcg/ml IM/IV Injection levels?

The study found that high doses of these Mecobal 500 mcg/ml IM/IV Injection were actually harmful.

Can Mecobal 500 mcg/ml IM/IV Injection cause kidney stones?

Mecobal 500 mcg/ml IM/IV Injection have not been shown to be harmful to people with kidney stones.

How long Mecobal 500 mcg/ml IM/IV Injection can be taken?

Mecobal 500 mcg/ml IM/IV Injection for 2-4 weeks is associated with better outcome in nerve conduction velocity and neuropathic symptoms.

Who should not take Mecobal 500 mcg/ml IM/IV Injection?

You should not use Mecobal 500 mcg/ml IM/IV Injection if you are allergic to Mecobal 500 mcg/ml IM/IV Injection or cobalt. Tell your doctor if you have ever had Leber's disease or other form of optic nerve damage,an iron or folic acid deficiency.

What happens if I miss a dose of Mecobal 500 mcg/ml IM/IV Injection?

Use Mecobal 500 mcg/ml IM/IV Injection as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Can I overdose on Mecobal 500 mcg/ml IM/IV Injection?

You cannot overdose on Mecobal 500 mcg/ml IM/IV Injection because any excess you simply pee out. If you get Mecobal 500 mcg/ml IM/IV Injection shots, you may experience side effects like dizziness, nausea, and fatigue.