Methdilazine
Methdilazine Uses, Dosage, Side Effects, Food Interaction and all others data.
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
| Trade Name | Methdilazine |
| Availability | Discontinued |
| Generic | Methdilazine |
| Methdilazine Other Names | Methdilazine, Methdilazinum, Metodilazina |
| Type | |
| Formula | C18H20N2S |
| Weight | Average: 296.43 Monoisotopic: 296.13471934 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders
How Methdilazine works
Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Toxicity
Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.
Methdilazine Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Methdilazine Drug Interaction
Moderate: tiotropium, tiotropium, naloxone / oxycodone, naloxone / oxycodoneUnknown: enoxaparin, enoxaparin, levothyroxine, levothyroxine, metronidazole, metronidazole, alendronate, alendronate, methenamine, methenamine, esomeprazole, esomeprazole, acetaminophen, acetaminophen, clopidogrel, clopidogrel
Methdilazine Disease Interaction
Major: acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, asthma/COPD, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Elimination Route
Well absorbed in the digestive tract.
Innovators Monograph
You find simplified version here Methdilazine
