Methdilazinum

Methdilazinum Uses, Dosage, Side Effects, Food Interaction and all others data.

Methdilazinum is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazinum is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Trade Name Methdilazinum
Availability Discontinued
Generic Methdilazine
Methdilazine Other Names Methdilazine, Methdilazinum, Metodilazina
Type
Formula C18H20N2S
Weight Average: 296.43
Monoisotopic: 296.13471934
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Methdilazinum
Methdilazinum

Uses

Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders

How Methdilazinum works

Methdilazinum binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Toxicity

Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.

Methdilazinum Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

Elimination Route

Well absorbed in the digestive tract.

Innovators Monograph

You find simplified version here Methdilazinum

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http://classyfire.wishartlab.com/tax_nodes/C0001349
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
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http://www.genome.jp/dbget-bin/www_bget?cpd:C07175
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https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505472
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http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81470
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=29648
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6823
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1200959
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001070
http://www.pharmgkb.org/drug/PA164743018
https://en.wikipedia.org/wiki/Methdilazine
*** Taking medicines without doctor's advice can cause long-term problems.
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