Methotrimeprazine by Pro Doc Limitee
Methotrimeprazine by Pro Doc Limitee Uses, Dosage, Side Effects, Food Interaction and all others data.
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Methotrimeprazine by Pro Doc Limitee is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
| Trade Name | Methotrimeprazine by Pro Doc Limitee |
| Availability | Discontinued |
| Generic | Methotrimeprazine |
| Methotrimeprazine Other Names | 2-Methoxytrimeprazine, Levomepromazina, Levomepromazine, Lévomépromazine, Levomepromazinum, Methotrimeprazine |
| Type | |
| Formula | C19H24N2OS |
| Weight | Average: 328.472 Monoisotopic: 328.16093409 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Canada, United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Methotrimeprazine by Pro Doc Limitee is a phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
Methotrimeprazine by Pro Doc Limitee is also used to associated treatment for these conditions: Amnesia, Anxiety, Bipolar Affective Disorders, Nausea and vomiting, Pain, Cancer, Phantom Limb Pain (PLP), Post-Herpetic Neuralgia (PHN), Schizophrenia, Senile psychosis, Trigeminal Neuralgia (TN), Neurocostal neuralgia, Perioperative analgesia
How Methotrimeprazine by Pro Doc Limitee works
Methotrimeprazine by Pro Doc Limitee's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.
Toxicity
Symptoms of overdose include convulsions, spastic movements, and coma.
Food Interaction
- Take with food. Food reduces irritation.
Methotrimeprazine by Pro Doc Limitee Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Methotrimeprazine by Pro Doc Limitee Drug Interaction
Moderate: aripiprazole, aripiprazole, celecoxib, celecoxib, duloxetine, duloxetine, fentanyl, fentanyl, morphine, morphine, quetiapine, quetiapineUnknown: acetaminophen, acetaminophen, levothyroxine, levothyroxine, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol
Methotrimeprazine by Pro Doc Limitee Disease Interaction
Elimination Route
Methotrimeprazine by Pro Doc Limitee has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.
Half Life
Approximately 20 hours.
Innovators Monograph
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