Methylenedioxymethamphetamine
Methylenedioxymethamphetamine Uses, Dosage, Side Effects, Food Interaction and all others data.
An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems.
MDMA acts as a releasing agent of serotonin, norepinephrine, and dopamine.
| Trade Name | Methylenedioxymethamphetamine |
| Generic | Midomafetamine |
| Midomafetamine Other Names | Ecstasy, MDMA, Methylenedioxymethamphetamine, Midomafetamine |
| Type | |
| Formula | C11H15NO2 |
| Weight | Average: 193.2423 Monoisotopic: 193.110278729 |
| Groups | Experimental, Illicit, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used illicit drugs in the U.S.
How Methylenedioxymethamphetamine works
It enters neurons via carriage by the monoamine transporters. Once inside, MDMA inhibits the vesicular monoamine transporter, which results in increased concentrations of serotonin, norepinephrine, and dopamine into the cytoplasm, and induces their release by reversing their respective transporters through a process known as phosphorylation. It also acts as a weak 5-HT1 and 5-HT2 receptor agonist. MDMA's unusual entactogenic effects have been hypothesized to be, at least partly, the result of indirect oxytocin secretion via activation of the serotonin system. Oxytocin is a hormone released following events like hugging, orgasm, and childbirth, and is thought to facilitate bonding and the establishment of trust. Based on studies in rats, MDMA is believed to cause the release of oxytocin, at least in part, by both directly and indirectly agonizing the serotonin 5-HT1A receptor.
Half Life
6–10 (though duration of effects is typically actually 3–5 hours)
Elimination Route
renal
Innovators Monograph
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