Mitotane

Mitotane Uses, Dosage, Side Effects, Food Interaction and all others data.

A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Trade Name Mitotane
Availability Prescription only
Generic Mitotane
Mitotane Other Names Mitotan, Mitotane, Mitotano, Mitotanum
Related Drugs Lysodren
Weight 500mg
Type Oral tablet
Formula C14H10Cl4
Weight Average: 320.041
Monoisotopic: 317.953661148
Protein binding

6%

Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Mitotane
Mitotane

Uses

Mitotane is an adrenal cortex inhibitor used to treat adrenocortical tumors and Cushing's syndrome.

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Mitotane is also used to associated treatment for these conditions: Cushing's Syndrome, Inoperable Adrenocortical carcinoma

How Mitotane works

Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Elimination Route

About 40% oral Lysodren is absorbed

Half Life

18-159 days

Elimination Route

A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.

Innovators Monograph

You find simplified version here Mitotane

*** Taking medicines without doctor's advice can cause long-term problems.
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