Mitotane
Mitotane Uses, Dosage, Side Effects, Food Interaction and all others data.
A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.
| Trade Name | Mitotane |
| Availability | Prescription only |
| Generic | Mitotane |
| Mitotane Other Names | Mitotan, Mitotane, Mitotano, Mitotanum |
| Related Drugs | Lysodren |
| Weight | 500mg |
| Type | Oral tablet |
| Formula | C14H10Cl4 |
| Weight | Average: 320.041 Monoisotopic: 317.953661148 |
| Protein binding | 6% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Mitotane is an adrenal cortex inhibitor used to treat adrenocortical tumors and Cushing's syndrome.
For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Mitotane is also used to associated treatment for these conditions: Cushing's Syndrome, Inoperable Adrenocortical carcinoma
How Mitotane works
Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Mitotane Drug Interaction
Major: acetaminophen / hydrocodone, acetaminophen / hydrocodoneModerate: diltiazem, diltiazemUnknown: rosuvastatin, rosuvastatin, glucose, glucose, dehydroepiandrosterone, dehydroepiandrosterone, metoprolol, metoprolol, metoprolol, metoprolol, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol, menaquinone, menaquinone
Mitotane Disease Interaction
Major: adrenal insufficiencyModerate: depression, liver dysfunction, neurologic disorder, perimenopause
Elimination Route
About 40% oral Lysodren is absorbed
Half Life
18-159 days
Elimination Route
A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.
Innovators Monograph
You find simplified version here Mitotane
