Moramin

Moramin Uses, Dosage, Side Effects, Food Interaction and all others data.

Moramin is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.

When injected intravenously, ethanolamine oleate acts primarily by irritation of the intimal endothelium of the vein and produces a sterile dose-related inflammatory response. This results in fibrosis and possible occlusion of the vein. Moramin also rapidly diffuses through the venous wall and produces a dose-related extravascular inflammatory reaction.

Trade Name Moramin
Generic Ethanolamine oleate
Ethanolamine oleate Other Names Ethamolin, Ethanolamine oleate, Monoethanolamine oleate, Monoethanolamini oleas, Oldamin, Oleate de monoethanolamine, Oleato de monoetanolaminio
Type
Formula C20H41NO3
Weight Average: 343.5444
Monoisotopic: 343.308644183
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Moramin
Moramin

Uses

Moramin is a mild sclerosing agent used in the treatment of esophageal varices with recent bleeding episodes.

For the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.

Moramin is also used to associated treatment for these conditions: Varices, Esophageal

How Moramin works

The oleic acid component of ethanolamine oleate is responsible for the inflammatory response, and may also activate coagulation in vivo by release of tissue factor and activation of Hageman factor. The ethanolamine component, however, may inhibit fibrin clot formation by chelating calcium, so that a procoagulant action of ethanolamine oleate has not been demonstrated.

Toxicity

The minimum lethal dose administered intravenously to rabbits is 130 mg/kg. Overdosage can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death. LD50 (intravenous) in rats is 156 mg/kg. LD50 (intravenous) in dogs is 175 mg/kg.

Food Interaction

No interactions found.

Elimination Route

After injection into an esophageal varix, ethanolamine oleate is cleared from the injection site within five minutes via the portal vein. Some of the medication also flows into the azygos vein through the periesophageal vein if more than 20 mL is injected.

Innovators Monograph

You find simplified version here Moramin

*** Taking medicines without doctor's advice can cause long-term problems.
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