Myoview

Myoview Uses, Dosage, Side Effects, Food Interaction and all others data.

Myoview was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Myoview is part of the group of diphosphines. Myoview is used in conjunction with technetium Tc-99m as a radiopharmaceutical.

Refer to Technetium Tc-99m tetrofosmin

Myoview
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Myoview
Availability	Prescription only
Generic	Tetrofosmin
Tetrofosmin Other Names	Tetrofosmin, Tetrofosmina
Related Drugs	glucagon, mannitol, Tubersol, arginine, inulin
Type	Injection
Formula	C₁₈H₄₀O₄P₂
Weight	Average: 382.462 Monoisotopic: 382.240183764
Protein binding	Refer to Technetium Tc-99m tetrofosmin
Groups	Approved
Therapeutic Class
Manufacturer	Ge Healthcare, Ge Healthcare Limited, Ge Healthcare Bio-sciences, Sa
Available Country	United States, Netherlands, Portugal, Spain
Last Updated:	September 19, 2023 at 7:00 am

Uses

Myoview is a diphosphine complexed with technetium 99 used for imaging to determine myocardial ischemia, infarcted myocardium, and assessment of left ventricular function.

Myoview is indicated to be used as a complex with technetium Tc-99m for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It helps in the delineation of regions of reversible myocardial ischemia in absence of infarcted myocardium.

This complex is also used for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease.

This complex is indicated for the assessment of left ventricular function in patients evaluated for heart disease.

Myoview is also used to associated treatment for these conditions: Breast Cancer, Hypoperfusion, Myocardial Infarction

How Myoview works

Myoview normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.

Toxicity

The toxicity of tetrofosmin as an individual agent has not been studied.

Food Interaction

Take with food. Some studies have found that this improves imaging.

Myoview Drug Interaction

Moderate: metoprololUnknown: lactobacillus acidophilus, ibuprofen, fexofenadine, aspirin, diphenhydramine, loratadine, ubiquinone, copper gluconate, cilgavimab / tixagevimab, omega-3 polyunsaturated fatty acids, nirmatrelvir / ritonavir, bioflavonoids, urea, pyridoxine, ascorbic acid, cholecalciferol, zinc sulfate

Volume of Distribution

This pharmacokinetic property has not been fully studied.

Elimination Route

After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.