Methazolamide Uses, Dosage, Side Effects and more
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.
| Trade Name | Methazolamide |
| Availability | Prescription only |
| Generic | Methazolamide |
| Methazolamide Other Names | Metazolamida, Methazolamid, Méthazolamide, Methazolamide, Methazolamidum, Methenamide, Neptazaneat |
| Related Drugs | acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic |
| Weight | 25mg, 50mg |
| Type | Oral tablet |
| Formula | C5H8N4O3S2 |
| Weight | Average: 236.26 Monoisotopic: 236.003782482 |
| Protein binding | 55% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Methazolamide is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
Methazolamide is also used to associated treatment for these conditions: Open-angle Glaucoma (OAG), Acute Angle closure glaucoma
How Methazolamide works
Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Toxicity
Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.
Food Interaction
- Drink plenty of fluids.
- Take with food.
Drug Interaction
Moderate: brinzolamide ophthalmic, brinzolamide ophthalmic, duloxetine, duloxetineUnknown: sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, brimonidine / timolol ophthalmic, brimonidine / timolol ophthalmic, meperidine, meperidine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, bimatoprost ophthalmic, bimatoprost ophthalmic, pregabalin, pregabalin, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol
Disease Interaction
Major: bone marrow depression/blood dyscrasias, adrenal insufficiency, closed-angle glaucoma, hypokalemia, hyponatremia, severe kidney disease, severe liver diseaseModerate: respiratory acidosis, diabetes mellitus, gout, metabolic acidosis
Volume of Distribution
- 17 to 23 L
Elimination Route
Methazolamide is well absorbed from the gastrointestinal tract.
Half Life
14 hours
