N-trimethylethanolamine

N-trimethylethanolamine Uses, Dosage, Side Effects, Food Interaction and all others data.

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh). N-trimethylethanolamine is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. N-trimethylethanolamine also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. N-trimethylethanolamine has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. N-trimethylethanolamine deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth.

N-trimethylethanolamine
Uses
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	N-trimethylethanolamine
Availability	Discontinued
Generic	Choline
Choline Other Names	Bilineurine, N-trimethylethanolamine, N,N,N-trimethylethanol-ammonium, trimethylethanolamine, Vitamin J
Type
Formula	C₅H₁₄NO
Weight	Average: 104.1708 Monoisotopic: 104.107539075
Groups	Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

N-trimethylethanolamine is a nutrient found in a wide variety of vitamins including pre-natal formulations.

For nutritional supplementation, also for treating dietary shortage or imbalance

N-trimethylethanolamine is also used to associated treatment for these conditions: Nutritional supplementation

How N-trimethylethanolamine works

N-trimethylethanolamine is a major part of the polar head group of phosphatidylcholine. Phosphatidylcholine's role in the maintenance of cell membrane integrity is vital to all of the basic biological processes: information flow, intracellular communication and bioenergetics. Inadequate choline intake would negatively affect all these processes. N-trimethylethanolamine is also a major part of another membrane phospholipid, sphingomyelin, also important for the maintenance of cell structure and function. It is noteworthy and not surprising that choline deficiency in cell culture causes apoptosis or programmed cell death. This appears to be due to abnormalities in cell membrane phosphatidylcholine content and an increase in ceramide, a precursor, as well as a metabolite, of sphingomyelin. Ceramide accumulation, which is caused by choline deficiency, appears to activate Caspase, a type of enzyme that mediates apoptosis. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Betaine is one of the factors that maintains low levels of homocysteine by resynthesizing L-methionine from homocysteine. Elevated homocysteine levels are a significant risk factor for atherosclerosis, as well as other cardiovascular and neurological disorders. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease.