Naptazane
Naptazane Uses, Dosage, Side Effects, Food Interaction and all others data.
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Naptazane is topical carbonic anhydrase inhibitor. Naptazane is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Naptazane is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Naptazane has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.
| Trade Name | Naptazane |
| Availability | Prescription only |
| Generic | Methazolamide |
| Methazolamide Other Names | Metazolamida, Methazolamid, Méthazolamide, Methazolamide, Methazolamidum, Methenamide, Neptazaneat |
| Related Drugs | acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic |
| Type | |
| Formula | C5H8N4O3S2 |
| Weight | Average: 236.26 Monoisotopic: 236.003782482 |
| Protein binding | 55% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Naptazane is a carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
Naptazane is also used to associated treatment for these conditions: Open-angle Glaucoma (OAG), Acute Angle closure glaucoma
How Naptazane works
Naptazane is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Toxicity
Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.
Food Interaction
- Drink plenty of fluids.
- Take with food.
Naptazane Drug Interaction
Moderate: brinzolamide ophthalmic, brinzolamide ophthalmic, duloxetine, duloxetineUnknown: sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, brimonidine / timolol ophthalmic, brimonidine / timolol ophthalmic, meperidine, meperidine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, bimatoprost ophthalmic, bimatoprost ophthalmic, pregabalin, pregabalin, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol
Volume of Distribution
- 17 to 23 L
Elimination Route
Naptazane is well absorbed from the gastrointestinal tract.
Half Life
14 hours
Innovators Monograph
You find simplified version here Naptazane
