Neoxazol

Neoxazol Uses, Dosage, Side Effects, Food Interaction and all others data.

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Neoxazol is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Neoxazol
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Neoxazol
Availability	Discontinued
Generic	Sulfisoxazole
Sulfisoxazole Other Names	Sulfadimethylisoxazole, Sulfafurazol, Sulfafurazole, Sulfafurazolum, Sulfaisoxazole, Sulfasoxazole, Sulfisonazole, Sulfisoxasole, Sulfisoxazol, Sulfisoxazole, Sulfofurazole, Sulphadimethylisoxazole, Sulphafurazol, Sulphafurazole, Sulphaisoxazole, Sulphisoxazol, Sulphofurazole
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, dexamethasone, levofloxacin
Type
Formula	C₁₁H₁₃N₃O₃S
Weight	Average: 267.304 Monoisotopic: 267.067761987
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Neoxazol is a sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.

For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Neoxazol is also used to associated treatment for these conditions: Acute Otitis Media

How Neoxazol works

Neoxazol is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Toxicity

LD₅₀=6800 mg/kg (Orally in mice)

Food Interaction

No interactions found.

Neoxazol Drug Interaction

Moderate: lactobacillus acidophilusUnknown: fluticasone / salmeterol, amoxicillin, multivitamin, sulfamethoxazole / trimethoprim, meperidine, albuterol / ipratropium, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, ofloxacin, penicillin v potassium, montelukast, tiotropium, budesonide / formoterol, benzonatate, ampicillin / sulbactam, albuterol, albuterol, cholecalciferol

Neoxazol Disease Interaction

Major: colitis, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: crystalluria, hemodialysis, urinary obstruction

Elimination Route

The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is intact drug, with the remaining as the N4-acetylated metabolite. It is excreted in human milk.