Urovist
Urovist Uses, Dosage, Side Effects, Food Interaction and all others data.
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Urovist sodium, it is used for gastrointestinal studies, angiography, and urography.
Urovist is the most commonly used water-soluble, iodinated, radiopaque x-ray contrast medium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues. The contrast will help the doctor see any special conditions that may exist in that organ or part of the body.
| Trade Name | Urovist |
| Availability | Prescription only |
| Generic | Diatrizoate |
| Diatrizoate Other Names | Acide amidotrizoique, Acidum amidotrizoicum, Acidum diacetylaminotrijodbenzoicum, Amidotrizoate, Amidotrizoic Acid, Diatrizoesaure, Diatrizoic acid, Methalamic acid, Triombrin, Urografin acid, Urogranoic acid |
| Related Drugs | glucagon, mannitol, Tubersol, arginine, inulin |
| Type | |
| Formula | C11H9I3N2O4 |
| Weight | Average: 613.9136 Monoisotopic: 613.769637046 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Urovist is an injected contrast agent used in radiology.
Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium.
How Urovist works
Urovist is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.
Toxicity
High osmolal radiocontrast agents like diatrizoate are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Food Interaction
No interactions found.Urovist Drug Interaction
Moderate: amlodipine, amlodipineUnknown: cefazolin, cefazolin, hydralazine, hydralazine, citalopram, citalopram, warfarin, warfarin, insulin lispro, insulin lispro, insulin lispro, insulin lispro, potassium chloride, potassium chloride, enoxaparin, enoxaparin, gabapentin, gabapentin
Urovist Disease Interaction
Major: pheochromocytomaModerate: congestive heart failure, multiple myeloma, myasthenia gravis, asthma/allergies
Elimination Route
However, it is not metabolized but excreted unchanged in the urine, each diatrizoate molecule remaining "obligated" to its sodium moiety. The liver and small intestine provide the major alternate route of excretion for diatrizoate. Injectable radiopaque diagnostic agents are excreted unchanged in human milk. Saliva is a minor secretory pathway for injectable radiopaque diagnostic agents.
Innovators Monograph
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FAQ
What is Urovist?
Urovist is a type of radiopaque contrast agent that is used during medical imaging tests such as X-rays, CT scans, and angiography. It helps to enhance the visibility of blood vessels, organs, and other internal structures in the body during these procedures.
How is rand administered?
Urovist is typically administered intravenously (through a vein) or orally (by mouth) depending on the type of imaging test being performed. It may also be administered rectally or directly into the bladder in certain cases.
What is Urovist used for?
Urovist is primarily used for medical imaging tests to help healthcare providers diagnose and monitor various medical conditions. It is commonly used for imaging the urinary tract, gastrointestinal tract, and blood vessels.
How does Urovist work?
Urovist is a radiopaque contrast agent that absorbs X-rays and other forms of radiation differently than surrounding tissues in the body. This differential absorption creates a contrast that enhances the visibility of internal structures during medical imaging tests.
What are the side effects of Urovist?
Some common side effects of Urovist may include headache, nausea, vomiting, flushing, and a metallic taste in the mouth. More serious side effects, such as allergic reactions or kidney damage, may occur in rare cases.
Who should not take Urovist?
Patients with a history of allergic reactions to contrast agents or iodine should not receive Urovist. Additionally, patients with kidney disease or a history of severe allergic reactions may need to be monitored more closely or may not be eligible for Diatrizoate administration.
What precautions should be taken before taking Urovist?
Patients should inform their healthcare provider if they have any allergies, medical conditions, or are taking any medications before receiving Urovist. Patients may also be asked to fast or follow other specific instructions before the imaging test.
How is Urovist eliminated from the body?
Urovist is eliminated from the body primarily through the kidneys and urinary tract. Patients may be advised to drink extra fluids after the imaging test to help flush the contrast agent out of their system.
How long does Urovist stay in the body?
The elimination half-life of Urovist ranges from 1 to 3 hours. However, the length of time it stays in the body may vary depending on factors such as the dose, the patient's kidney function, and the imaging test performed.
Are there any risks associated with Urovist?
Like all contrast agents, Urovist carries a risk of allergic reactions, including anaphylaxis. It may also cause kidney damage in patients with pre-existing kidney disease. Patients with a history of allergies, asthma, or kidney disease should inform their healthcare provider before undergoing an imaging test with Urovist.
Can Urovist be used during pregnancy?
Urovist is generally avoided during pregnancy, especially during the first trimester, as its effects on the developing fetus are not well-known. Pregnant women should discuss the risks and benefits of Urovist use with their healthcare provider.
Can Urovist be used during breastfeeding?
It is not known whether Urovist passes into breast milk. Women who are breastfeeding should inform their healthcare provider before undergoing an imaging test with Urovist.
What other medications or substances should be avoided before Urovist administration?
Patients should inform their healthcare provider if they are taking medications that affect the kidneys, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or certain antibiotics. Patients may also be advised to avoid eating or drinking before the imaging test to reduce the risk of nausea and vomiting.
How is Urovist different from other contrast agents?
Urovist is an iodine-containing contrast agent that is commonly used for imaging tests such as X-rays and CT scans. Other contrast agents, such as gadolinium-based agents, are used for MRI scans. Each type of contrast agent has its own advantages and limitations, and the choice of agent will depend on the specific imaging needs of the patient.
How is Urovist stored?
Urovist should be stored at room temperature, away from light and moisture. It should not be frozen or exposed to extreme heat. The medication should be properly disposed of after use.
