Nidrel
Nidrel Uses, Dosage, Side Effects, Food Interaction and all others data.
Nidrel is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Nidrel, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nidrel is similar to other peripheral vasodilators. Nidrel inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
| Trade Name | Nidrel |
| Generic | Nitrendipine |
| Nitrendipine Other Names | Nitrendipine, Nitrendipino, Nitrendipinum |
| Type | |
| Formula | C18H20N2O6 |
| Weight | Average: 360.3612 Monoisotopic: 360.132136382 |
| Protein binding | > 99% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nidrel is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension.
For the treatment of mild to moderate hypertension
Nidrel is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)
How Nidrel works
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nidrel inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Food Interaction
- Take with or without food.
Innovators Monograph
You find simplified version here Nidrel
