Nitrilotriethanol
Nitrilotriethanol Uses, Dosage, Side Effects, Food Interaction and all others data.
Nitrilotriethanol, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Nitrilotriethanol contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats . It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products.
Acts as a surfactant or alkalizing agent to aid in emulsification and solubilizing of compounds or in raising the pH of a solution
| Trade Name | Nitrilotriethanol |
| Generic | Trolamine |
| Trolamine Other Names | nitrilotriethanol, triethanolamine, tris(2-hydroxyethyl)amine, Trolamine |
| Type | |
| Formula | C6H15NO3 |
| Weight | Average: 149.1882 Monoisotopic: 149.105193351 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nitrilotriethanol is used as an alkalizing agent, surfactant, and counter-ion in cosmetic and pharmaceutical formulations . It is not considered to be an active pharmacological ingredient and so has no official indication.
Nitrilotriethanol is also used to associated treatment for these conditions: Soreness, Muscle
How Nitrilotriethanol works
As an amine, trolamine is capable of accepting a hydrogen to form hydroxide and a conjugate acid. This raises the pH of the solution. As a surfactant, it can lower the interfacial tension in a mixture or solution to prevent separation of emulsions or precipitation of a compound out of solution.
Toxicity
Nitrilotriethanol produced mild erythema and edema in rabbits with dermally administered doses of 2 g/kg under occlusion . The oral LD50 was found to be 8 g/kg in guinea pigs and 4.19-11.26 g/kg in rats. Repeated oral administration in rats and guinea pigs produced hepatic and renal damage with deaths occurring in rats at doses >0.3 g/kg/day. When inhaled trolamine produced edema and inflammation in rats at doses over 100 mg/m³ after 5 days and at doses over 4.7 mg/m³ after 90 days. There is some evidence of carcinogenicity at high dermal doses (1000 mg/kg/day) in mice. Nitrilotriethanol is not classified as a carcinogen in humans.
Food Interaction
No interactions found.Elimination Route
Dermal absorption of trolamine increases with the dose . This has been found to range from 19-28% in rats with doses of 68-276 mg/kg in 190 μL of acetone without occlusion and from 60-80% in mice with doses of 79-1120 mg/kg in the same volume of acetone.
Elimination Route
When orally administered to rats, the 53% of the trolamine dose was found to be excreted in the urine and 20% in the feces . 98% was excreted in the urine with intravenous administration.
Innovators Monograph
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