Norcisapride
Norcisapride Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Norcisapride |
| Generic | Ticalopride |
| Ticalopride Other Names | Norcisapride, Ticalopride |
| Type | |
| Formula | C14H20ClN3O3 |
| Weight | Average: 313.78 Monoisotopic: 313.119319228 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis.
How Norcisapride works
Norcisapride is an isomer of the active metabolite of cisapride. Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.
Innovators Monograph
You find simplified version here Norcisapride
