Novobiocin
Novobiocin Uses, Dosage, Side Effects, Food Interaction and all others data.
Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.
Trade Name | Novobiocin |
Availability | Discontinued |
Generic | Novobiocin |
Novobiocin Other Names | Albamycin, Novobiocin, Novobiocina, Novobiocine, Novobiocinum |
Type | |
Formula | C31H36N2O11 |
Weight | Average: 612.6243 Monoisotopic: 612.231910004 |
Protein binding | 95% |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of infections due to staphylococci and other susceptible organisms
How Novobiocin works
Novobiocin is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Elimination Route
Oral bioavailability is negligible.
Half Life
6 hours
Innovators Monograph
You find simplified version here Novobiocin