Novobiocin

Novobiocin Uses, Dosage, Side Effects, Food Interaction and all others data.

Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)

Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

Trade Name Novobiocin
Availability Discontinued
Generic Novobiocin
Novobiocin Other Names Albamycin, Novobiocin, Novobiocina, Novobiocine, Novobiocinum
Type
Formula C31H36N2O11
Weight Average: 612.6243
Monoisotopic: 612.231910004
Protein binding

95%

Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Novobiocin
Novobiocin

Uses

For the treatment of infections due to staphylococci and other susceptible organisms

How Novobiocin works

Novobiocin is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Elimination Route

Oral bioavailability is negligible.

Half Life

6 hours

Innovators Monograph

You find simplified version here Novobiocin

*** Taking medicines without doctor's advice can cause long-term problems.
Share