Novobiocine Uses, Dosage, Side Effects and more

Novobiocine is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocine binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)

Novobiocine is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocine binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

Attribute	Details
Trade Name	Novobiocine
Availability	Discontinued
Generic	Novobiocin
Novobiocin Other Names	Albamycin, Novobiocin, Novobiocina, Novobiocine, Novobiocinum
Type
Formula	C₃₁H₃₆N₂O₁₁
Weight	Average: 612.6243 Monoisotopic: 612.231910004
Protein binding	95%
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	January 7, 2025 at 1:49 am

Uses

For the treatment of infections due to staphylococci and other susceptible organisms

How Novobiocine works

Novobiocine is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.