Oleic Acid
Oleic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
| Trade Name | Oleic Acid |
| Generic | Oleic Acid |
| Type | |
| Formula | C18H34O2 |
| Weight | Average: 282.4614 Monoisotopic: 282.255880332 |
| Protein binding | As with other fatty acids originating from adipose tissue stores, oleic acid may bind to serum albumin or remain unesterified in the blood . |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Oleic Acid is a naturally occurring fatty acid with antibacterial properties added to a variety of drug products.
Toxicity
In rat, oral LD50 74 g/kg and intravenous LD50 is 2.4 mg/kg . Dermal LD50 in guinea pig was >3000 mg/kg .
Food Interaction
No interactions found.Volume of Distribution
Radio-labelled oleic acid was detected in the heart, liver, lung, spleen, kidney, muscle, intestine, adrenal, blood, and lymph, and adipose, mucosal, and dental tissues . Oleic acid is primarily transported via the lymphatic system .
Elimination Route
Fatty acid uptake by different tissues may be mediated via passive diffusion to facilitated diffusion or a combination of both . Fatty acids taken up by tissues are then stored in the form of triglycerides or oxidized . Oleic acid was shown to penetrate rat skin . Following oral administration of Brucea javanica oil emulsion in rats, the time of oleic acid to reach peak plasma concentration was approximately 15.6 hours .
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
Following oral administration of trace amounts of oleic acid, less than 10% of total oleic acid was found to be eliminated via fecal excretion .
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