Oleoyl Estrone

Oleoyl Estrone Uses, Dosage, Side Effects, Food Interaction and all others data.

Oleoyl Estrone (OE) is a fatty acid ester of estrone. This hormone occurs naturally and is found circulating in various animal species and humans. It has been shown in animal studies to promote the loss of body fat while maintaining body protein storage, maintaining nitrogen balance. Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show that this drug appears to avoid this effect.

Oleoyl Estrone is a fatty acid ester of estrone, and may be directly involved in the control of body weight (PMID: 8782737).

Trade Name Oleoyl Estrone
Generic Oleoyl-estrone
Oleoyl-estrone Other Names Estrone monooleate, Estrone oleic acid ester, Oleoyl estrone, Oleoylestrone
Type
Formula C36H54O3
Weight Average: 534.8122
Monoisotopic: 534.407295594
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Oleoyl Estrone
Oleoyl Estrone

Uses

For the treatment of obesity.

How Oleoyl Estrone works

Based on extensive preclinical studies, it is believed that oleoyl-estrone (OE) works by a dual mechanism of action. Centrally, OE appears to act at the brain's hypothalamus, resetting the body's ponderostat, the “food control center” in the brain that detects and integrates signals that control both appetite and metabolic behavior. Peripherally, OE also causes reduced storage of fat in “white fat” tissue and allows skeletal muscle to use fat as an alternate energy source.

Elimination Route

Orally available

Innovators Monograph

You find simplified version here Oleoyl Estrone

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