Voacanginine
Voacanginine Uses, Dosage, Side Effects, Food Interaction and all others data.
Voacanginine is an alkaloid isolated from the bark of the Pescheria fuchsiae folia tree. It is an antimalarial drug approved for use in several African countries. Voacanginine is also under investigation for use in modulating multidrug-resistance in tumor cells.
Voacanginine is an anti-malarial extracted from the Brazilian tree Peschiera fuchsiaefolia. In one study (PMID: 11180519), the in vivo antiplasmodial activity of voacamine was assessed in a 4-day test. It was shown to exhibit in vivo activity with 25.4% and 43.4% inhibition of parasitaemia with 2.5 and 10 mg/kg, respectively. In synchronized cultures, it was found to act on trophozoite and schizont stages of Plasmodium falciparum.Voacanginine is a bisindolic alkaloid under investigation for modulation of multidrug resistance to enhance anticancer drugs such as doxorubicin.
| Trade Name | Voacanginine |
| Generic | Voacamine |
| Voacamine Other Names | Voacanginine, Vocamine |
| Type | |
| Formula | C43H52N4O5 |
| Weight | Average: 704.8968 Monoisotopic: 704.393770794 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells.
How Voacanginine works
Voacanginine is possibly a substrate for P-glycoprotein (P-gp), an efflux pump responsible for multidrug resistance in tumor cells. Voacanginine may compete with anticancer drugs such as doxorubicin for P-gp transport, decreasing removal of doxorubicin.
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