Orbcel-C
Orbcel-C Uses, Dosage, Side Effects, Food Interaction and all others data.
ORBCEL-C™ is the trade name of a product composed of highly purified stromal cells derived from the human umbilical cord. The isolated cells are expanded in culture and are able to be used allogenically -- meaning that one donor’s cells can be given to other unrelated patients. These cells are CD362 enriched umbilical cord-derived mesenchymal stem cells (UC-MSCs); UC-MSCs share stemness markers with both embryonic stem cells (ESCs) and adult mesenchymal stem cells (MSCs); this feature allows them to be hypoimmunogenic and non-inducible for tumorigenesis.
Regarding the modifications of these UC-MSCs, CD362, also known as syndecan-2, is a surface marker identified on MSCs with enhanced clonogenicity and immunomodulatory properties. Enrichment of CD362 expression in MSCs is being investigated for its role in immune modulation of injured tissue.
| Trade Name | Orbcel-C |
| Generic | Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells |
| Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells Other Names | Allogeneic donor CD362 enriched human umbilical cord-derived mesenchymal stromal cells, ORBCEL C™, Orbcel-C, REALIST ORBCEL-C |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How Orbcel-C works
The mesenchymal stem cells (MSCs) of ORBCEL-C™ act through release of factors which reduce inflammatory responses, promote blood vessel formation, and have the ability to demonstrate immunomodulatory effects.
Allogeneic UC-MSCs are also being investigated in orthopedic applications for cartilage and bone regeneration; these UC-MSCs are a valuable allogeneic source of cells as these cells are from a discarded material with virtually unlimited availability. Specifically to orthopedics, UC-MSCs have potential for treatment of chondral and osteochondral lesions, and bone defects as a universal off-the-shelf product.
Innovators Monograph
You find simplified version here Orbcel-C
