OXI4503

OXI4503 Uses, Dosage, Side Effects, Food Interaction and all others data.

OXI4503 is investigated in clinical trials for treating cancer/tumors. OXI4503 is a solid. OXI4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. OXI4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular disrupting agent (VDA). In addition, however, preclinical data demonstrates that OXI4503 is metabolized by oxidative enzymes (e.g., tyrosinase and peroxidases), which are elevated in many solid tumors and tumor infiltrates, to an orthoquinone chemical species that has direct cytotoxic effects on tumor cells. Preclinical studies have demonstrated that OXI4503 has (i) single-agent activity against a range of xenograft tumor models; and (ii) synergistic or additive effects when incorporated in various combination regimens with chemotherapy, molecularly-targeted therapies (including tumor-angiogenesis inhibitors), and radiation therapy.

OXi4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. In addition, however, preclinical data demonstrates that OXi4503 is metabolized by oxidative enzymes (e.g., tyrosinase and peroxidases), which are elevated in many solid tumors and tumor infiltrates, to an orthoquinone chemical species that has direct cytotoxic effects on tumor cells.

Trade Name OXI4503
Generic OXI-4503
OXI-4503 Other Names CA1P, OXI4503
Type
Formula C18H22O12P2
Weight Average: 492.31
Monoisotopic: 492.058650144
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
OXI4503
OXI4503

Uses

Investigated for use/treatment in cancer/tumors (unspecified).

How OXI4503 works

OXi4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. It induced the shutdown of tumor blood vessels and affected peripheral tumor regions less than central regions.

Innovators Monograph

You find simplified version here OXI4503

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