Oxprenolol Amdipharm

Oxprenolol Amdipharm Uses, Dosage, Side Effects, Food Interaction and all others data.

A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

Oxprenolol Amdipharm is a non-selective beta blocker with some intrinsic sympathomimetic activity. Oxprenolol Amdipharm is a lipophilic molecule and hence, it is able to cross the blood-brain barrier. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. Oxprenolol Amdipharm is an potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.

Trade Name Oxprenolol Amdipharm
Generic Oxprenolol
Oxprenolol Other Names Oxprenolol, Oxprenololum
Type
Formula C15H23NO3
Weight Average: 265.348
Monoisotopic: 265.167793607
Groups Approved
Therapeutic Class
Manufacturer
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Oxprenolol Amdipharm
Oxprenolol Amdipharm

Uses

Oxprenolol Amdipharm is a non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety.

Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

How Oxprenolol Amdipharm works

Like other beta-adrenergic antagonists, oxprenolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, oxprenolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure. It also blocks beta-2 adrenergic receptors located in bronchiole smooth muscle, causing vasoconstriction. By binding beta-2 receptors in the juxtaglomerular apparatus, oxprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production. Oxprenolol Amdipharm therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.

Toxicity

Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.

Food Interaction

  • Avoid alcohol.
  • Avoid natural licorice.
  • Take with or without food. The absorption is unaffected by food.

Elimination Route

Oral bioavailability is 20-70%.

Half Life

1-2 hours

Innovators Monograph

You find simplified version here Oxprenolol Amdipharm

*** Taking medicines without doctor's advice can cause long-term problems.
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