Oxprenololum
Oxprenololum Uses, Dosage, Side Effects, Food Interaction and all others data.
A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
Oxprenololum is a non-selective beta blocker with some intrinsic sympathomimetic activity. Oxprenololum is a lipophilic molecule and hence, it is able to cross the blood-brain barrier. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. Oxprenololum is an potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.
| Trade Name | Oxprenololum |
| Generic | Oxprenolol |
| Oxprenolol Other Names | Oxprenolol, Oxprenololum |
| Type | |
| Formula | C15H23NO3 |
| Weight | Average: 265.348 Monoisotopic: 265.167793607 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Oxprenololum is a non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety.
Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
How Oxprenololum works
Like other beta-adrenergic antagonists, oxprenolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, oxprenolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure. It also blocks beta-2 adrenergic receptors located in bronchiole smooth muscle, causing vasoconstriction. By binding beta-2 receptors in the juxtaglomerular apparatus, oxprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production. Oxprenololum therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
Toxicity
Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.
Food Interaction
- Avoid alcohol.
- Avoid natural licorice.
- Take with or without food. The absorption is unaffected by food.
Elimination Route
Oral bioavailability is 20-70%.
Half Life
1-2 hours
Innovators Monograph
You find simplified version here Oxprenololum
