Padimate O

Padimate O Uses, Dosage, Side Effects, Food Interaction and all others data.

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to Aminobenzoic acid that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand breaks on DNA in vitro and mutagenic effects on yeast in vivo .

Padimate O absorbs UV-B rays, which can in turn induce DNA damage in human keratinocytes. While treatment of padimate O suppresses the formation of UV-endonuclease-sensitive sites, there is also an increase in direct strand breaks of DNA in cells .

Padimate O
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Padimate O
Generic	Padimate O
Padimate O Other Names	Padimate O, Padimate-O
Type
Formula	C₁₇H₂₇NO₂
Weight	Average: 277.408 Monoisotopic: 277.204179113
Protein binding	No pharmacokinetic data available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Padimate O is an ingredient used in sunscreens to absorb UV radiation.

Indicated as an active UV-B filter to prevent photodamage.

How Padimate O works

It is proposed that simultaneous contact of padimate O with keratinocytes can stimulate the diffusion through human epidermis. Upon photoexcitation, padimate O generates singlet oxygen and forms carbon-centred free radicals. While padimate O attenuates simple and repairable, UV-induced cellular damage, it may also increase complex chemical damage that is more difficult to repair by normal cells .