Pancreatic Lipase

Pancreatic Lipase Uses, Dosage, Side Effects, Food Interaction and all others data.

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase lipase is an enzyme secreted by the pancreas that is responsible for the hydrolysis of dietary fat molecules in the human digestive system. The pancrelipase mixture, including pancrelipase lipase, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010.

Please refer to Pancrelipase.

Pancreatic Lipase
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Pancreatic Lipase
Generic	Pancrelipase lipase
Pancrelipase lipase Other Names	Lipase, pancreatic, Pancreatic lipase
Type
Weight	48000.0 Da
Protein binding	Please refer to Pancrelipase.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pancreatic Lipase is a lipase used to treat pancreatic exocrine insufficiency.

Please refer to Pancrelipase.

Pancreatic Lipase is also used to associated treatment for these conditions: Exocrine Pancreatic Insufficiency, Pancreatic Insufficiency, Pancreatic enzyme replacement

How Pancreatic Lipase works

Pancreatic Lipase catalyzes the hydrolysis of triglycerides to monoglycerides, glycerol, and fatty acids. This activity is performed by the hydrolyzation of the esters of fatty acids. The hydrolysis is started by the action of colipase which helps to anchor lipase to the lipid-water membrane of the micelle producing a surface change on lipase. The hydrophobic active site is exposed for the binding of triglycerides and further interaction with the catalytic triad. In this triad, the function of the three amino acids allows the formation of a deprotonated serine which becomes a nucleophile and act on the ester carbonyl of the fatty acids for the later formation of monoglyceride and fatty acid monomers.