Panzem
Panzem Uses, Dosage, Side Effects, Food Interaction and all others data.
Panzem (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Panzem belongs to the family of drugs called angiogenesis inhibitors. It also acts as a vasodilator.
| Trade Name | Panzem |
| Generic | 2-Methoxyestradiol |
| 2-Methoxyestradiol Other Names | 2-ME2, 2-Methoxyestradiol-17beta, 2ME2 |
| Type | |
| Formula | C19H26O3 |
| Weight | Average: 302.4079 Monoisotopic: 302.188194698 |
| Protein binding | 2ME2 was found to bind in decreasing order to plasma>albumin>alpha1-acid glycoprotein>sex-hormone-binding globulin. Plasma concentration-time profiles of total 2ME2 and unbound 2ME2 concentrations in a patient with cancer receiving 2ME2 as a single oral dose were parallel to each other. Thus, indicating that plasma protein binding is not an important consideration in pharmacokinetic monitoring of 2ME2. |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis.
How Panzem works
Panzem is an angiogenesis inhibitor, and has been shown to attack both tumor cells and their blood supply in preclinical testing. 2-methoxyestradiol is a naturally occurring estrogen metabolite but has no undesired estrogenic activity.
Innovators Monograph
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