Parathyroid Hormone
Parathyroid Hormone Uses, Dosage, Side Effects, Food Interaction and all others data.
Parathyroid Hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa).
Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures and is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA).
Parathyroid Hormone is responsible for the fine regulation of serum calcium concentration on a minute-to-minute basis. This is achieved by the acute effects of the hormone on calcium resorption in bone and calcium reabsorption in the kidney. The phosphate mobilized from bone is excreted into the urine by means of the hormone's influence on renal phosphate handling. Parathyroid Hormone also stimulates calcium absorption in the intestine, this being mediated indirectly by 1,25-dihydroxyvitamin D. Thus, a hypocalcemic stimulus of parathyroid hormone secretion results in an increased influx of calcium from three sources (bone, kidney, and intestine), resulting in a normalization of the serum calcium concentration without change in the serum phosphate concentration.
| Trade Name | Parathyroid Hormone |
| Generic | Parathyroid hormone |
| Parathyroid hormone Other Names | Parathormone, Parathormone (human recombinant), Parathyrin, Parathyroid hormone, PTH |
| Weight | 100mcg/dose, 25mcg/dose, 50mcg/dose, 75mcg/dose, |
| Type | Subcutaneous Powder For Injection, Subcutaneous |
| Formula | C408H674N126O126S2 |
| Weight | 9420.0 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Parathyroid Hormone is an analog of human parathyroid hormone (PTH) used to treat hypocalcemia caused by hypoparathyroidism.
For use/treatment in osteoporosis.
Parathyroid Hormone is also used to associated treatment for these conditions: Hypocalcemia, Hypoparathyroidism
How Parathyroid Hormone works
The biological actions of rhPTH are mediated through binding to at least two distinct high- affinity cell-surface receptors specific for the N-terminal and C-terminal regions of the molecule, both of which are required for normal bone metabolism. The N-terminal portion of the molecule is primarily responsible for the bone building effects of parathyroid hormone. The C-terminal portion of the molecule has antiresorptive activity and is necessary for normal regulation of N-terminal fragment activity.
Food Interaction
No interactions found.Volume of Distribution
The volume of distribution at steady-state following intravenous administration is approximately 5.4 liters with an interpatient variability of about 40%.
Elimination Route
The absolute bioavailability after subcutaneous administration in the abdomen is 55% for doses of 100 micrograms.
Half Life
1.5 hours.
Elimination Route
Carboxy-terminal fragments are filtered by the kidney and subsequently broken down into even smaller fragments during tubular reuptake.
Innovators Monograph
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