PEG-adenosine Deaminase

PEG-adenosine Deaminase Uses, Dosage, Side Effects, Food Interaction and all others data.

Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.

Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.

PEG-adenosine Deaminase
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	PEG-adenosine Deaminase
Availability	Discontinued
Generic	Pegademase
Pegademase Other Names	PEG-adenosine deaminase, pegADA, Pegademase, Pegademase bovine
Related Drugs	Adagen, Revcovi
Type
Formula	C₁₈₂₁H₂₈₃₄N₄₈₄O₅₅₂S₁₄
Weight	40788.2 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

PEG-adenosine Deaminase is a modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.

For treatment of adenosine deaminase deficiency

PEG-adenosine Deaminase is also used to associated treatment for these conditions: Adenosine Deaminase Deficiency

How PEG-adenosine Deaminase works

PEG-adenosine Deaminase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.