Pentolonium
Pentolonium Uses, Dosage, Side Effects, Food Interaction and all others data.
Pentolonium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Pentolonium acts as a ganglionic blocking agent. Pentolonium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
| Trade Name | Pentolonium |
| Generic | Pentolinium |
| Pentolinium Other Names | Pentolineum, Pentolonium, Pentolonum |
| Type | |
| Formula | C15H32N2 |
| Weight | Average: 240.428 Monoisotopic: 240.256549034 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
How Pentolonium works
Pentolonium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Toxicity
Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.
Innovators Monograph
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