Pentolonium

Pentolonium Uses, Dosage, Side Effects, Food Interaction and all others data.

Pentolonium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

Pentolonium acts as a ganglionic blocking agent. Pentolonium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.

Trade Name Pentolonium
Generic Pentolinium
Pentolinium Other Names Pentolineum, Pentolonium, Pentolonum
Type
Formula C15H32N2
Weight Average: 240.428
Monoisotopic: 240.256549034
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Pentolonium
Pentolonium

Uses

Used to produce controlled hypotension during surgical procedures and in hypertensive crises.

How Pentolonium works

Pentolonium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.

Toxicity

Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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