Ouabaine Uses, Dosage, Side Effects and more
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.
Ouabaine, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
| Trade Name | Ouabaine |
| Generic | Ouabain |
| Ouabain Other Names | G-Strophanthin, Ouabagenin L-Rhamnoside, Ouabagenin-L-rhamnosid, Ouabaine, Oubain |
| Type | |
| Formula | C29H44O12 |
| Weight | Average: 584.6525 Monoisotopic: 584.283276872 |
| Protein binding | 60% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
For the treatment of atrial fibrillation and flutter and heart failure
How Ouabaine works
Ouabaine inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabaine also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
