Peptosol
Peptosol Uses, Dosage, Side Effects, Food Interaction and all others data.
Aluminum hydroxide neutralizes stomach hydrocloride to form AICI3 salt plus water; increases gastric pH.
Magnesium Trisilicate neutralizes gastric acidity by increasing gastric pH
| Trade Name | Peptosol |
| Generic | Aluminium Oxide + Magnesium Trisilicate |
| Weight | (200mg+250mg)/5ml, 50mg/100ml |
| Type | Oral Suspension, Iv Infusion |
| Therapeutic Class | Antacid with laxative action, Antacids |
| Manufacturer | Globe Pharmaceuticals Limited, Opso Saline Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Aluminium Oxide & Magnesium Trisilicate is used for Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease, Gastroesophageal reflux disorder (GERD)
Peptosol is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating, Colic, Flatulence, Gastric Ulcer, Heartburn, Upset stomach
How Peptosol works
The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.
Dosage
Peptosol dosage
Take 2-4 teaspoonful after meals and at bedtime as needed (up to 4 times a day)
Side Effects
Diarrhoea, constipation, nausea, vomiting.
Toxicity
Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.
Precaution
Renal dysfunction, low phosphate diet, prolonged use.
Interaction
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Trisilicate: None well documented.
Volume of Distribution
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
Elimination Route
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
Half Life
16-20 hours
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Elimination Route
Excreted in the urine.
Pregnancy & Breastfeeding use
Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Contraindication
Hypophosphataemia
Innovators Monograph
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