Phacovit
Phacovit Uses, Dosage, Side Effects, Food Interaction and all others data.
Phacovit is a sterile eye drops containing Adenosine, Nicotinamide, Cytochrome C and Sodium Succinate. Cytochrome C helps in the oxidative phosphorylation for synthesizing ATP from ADP. Sodium Succinate (intermediate substance) promotes the production of ATP. Adenosine plays essential role in producing energy required for the vital function of the lens. Nicotinamide is involved in the process of creating ATP.
| Trade Name | Phacovit |
| Generic | Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide |
| Type | Eye Drops |
| Therapeutic Class | Drugs for lens opacification |
| Manufacturer | Aristopharma Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
This eye drops is used for the treatment of lens opacification.
Phacovit is also used to associated treatment for these conditions: Paroxysmal Supraventricular Tachycardia, SVT, Tachycardia, Supraventricular, Symptomatic pulmonary arterial hypertension (PAH)Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
How Phacovit works
Agonism of adenosine receptors A1 and A2 reduces conduction time in the atrioventricular node of the heart. Conduction time is decreased by inducing potassium efflux and inhibiting calcium influx through channels in nerve cells, leading to hyperpolarization and and increased threshold for calcium dependent action potentials. Decreased conduction time leads to an antiarrhythmic effect. Inhibition of calcium influx, reduces the activity of adenylate cyclase, relaxing vascular smooth muscle. Relaxed vascular smooth muscle leads to increased blood flow through normal coronary arteries but not stenotic arteries, allowing thallium-201 to be more readily uptaken in normal coronary arteries.
Dosage
Phacovit dosage
One drop into the affected eye twice daily.
Side Effects
Phacovit may cause more or less discomfort in some patients like any other drug. If any discomfort occurs, it is recommended to consult doctor.
Toxicity
Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived. Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of theophylline.
The LD50 in mice is >20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.[L32048]
Precaution
Only for topical ophthalmic use. Do not inject or swallow. In case of concomitant treatment with another ophthalmic solution, wait 15 minutes between each instillation.
Interaction
To avoid interaction with other drugs, it is recommended to inform your doctor of any concomitant treatment particularly with other eye drops.
Volume of Distribution
Data regarding the volume of distribution of adenosine are not readily available.
Elimination Route
Data regarding the absorption of adenosine are not readily available.
Half Life
The half life of adenosine in blood is less than 10 seconds.
Clearance
Data regarding the clearance of adenosine are not readily available.
Elimination Route
Adenosine is predominantly eliminated in the urine as uric acid.
Pregnancy & Breastfeeding use
In pregnancy and lactation, it is recommended to take advice from doctor before using Phacovit eye drops.
Contraindication
This eye drops is contraindicated in patients with known hypersensitivity to any ingredient of the product.
Acute Overdose
Generally it does not cause any toxicity even after accidental ingestion of the medicine due to low quantity of ingredients.
Interaction with other Medicine
No specific drug interaction has been demonstrated.
Storage Condition
Store in a cool, dry place & protected from light
Keep out of reach of children
Do not use more than 4 weeks after opening
Innovators Monograph
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