Pilimod

Pilimod Uses, Dosage, Side Effects, Food Interaction and all others data.

Pilimod is a synthetic dipeptide with immunomodulatory properties.

Pilimod modulates the immune system to induce an immune response against bacterial or viral pathogens

Trade Name Pilimod
Generic Pidotimod
Pidotimod Other Names Pidotimod
Type
Formula C9H12N2O4S
Weight Average: 244.27
Monoisotopic: 244.051778048
Groups Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Pilimod
Pilimod

Uses

Pilimod is a synthetic agent with immunomodulatory properties used in patients with documented cell-mediated immunosuppression to stimulate their immunity during lung and urinary tract infections.

For use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections .

Pilimod is also used to associated treatment for these conditions: Recurrent Upper Respiratory Tract Infection, Immunostimulation

How Pilimod works

Pilimod inhibits tumor necrosis factor α (TNF-α) induced increases in extracellular signal-related kinase (ERK) phosphorylation . It also increases nuclear factor κB (NFκB) expression and translocation to the nucleus. It is these to modulatory effects on ERK and NFκB signalling which are thought to produce the increase in toll-like receptor expression seen with pidotimod. Pilimod increase maturation of dendritic cells responsible for presenting antigens to naive Th-cells . It also appears to result in a greater population these cells diiferentiating to Th1 cells which are believed to mediate the immune response to pathogens like bacteria and viruses . Lastly, pidotimod appears to increase antigen-specific antibody titer and cytotoxic response with antigen exposure . The precise mechanism and timeline of events leading to these effects is unknown.

Elimination Route

Bioavailability of 45% .

Half Life

Half life of 4 h .

Elimination Route

95% of intravenous dose is eliminated in the urine as the parent compound .

Innovators Monograph

You find simplified version here Pilimod

*** Taking medicines without doctor's advice can cause long-term problems.
Share