Piportyl L-4

Piportyl L-4 Uses, Dosage, Side Effects, Food Interaction and all others data.

Piportyl L-4 has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.

Piportyl L-4 has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It reduces activity of dopamine receptors in the limbic system. Its 5-HT antagonism helps normalize dopamine activity in the cortical regions.

Piportyl L-4
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Volume of Distribution
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Interaction With other Medicine
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Trade Name	Piportyl L-4
Generic	Pipotiazine
Pipotiazine Other Names	Piportil, Pipothiazine, Pipotiazina, Pipotiazine, Pipotiazinum
Type
Formula	C₂₄H₃₃N₃O₃S₂
Weight	Average: 475.667 Monoisotopic: 475.196333317
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Chile
Last Updated:	September 19, 2023 at 7:00 am

Uses

Piportyl L-4 is an antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.

For the maintenance treatment of chronic non-agitated schizophrenic patients.

Piportyl L-4 is also used to associated treatment for these conditions: Chronic Schizophrenia

How Piportyl L-4 works

Piportyl L-4 acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).