Pivaloylampicillin

Pivaloylampicillin Uses, Dosage, Side Effects, Food Interaction and all others data.

Pivalate ester analog of ampicillin.

Pivaloylampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.

Trade Name Pivaloylampicillin
Generic Pivampicillin
Pivampicillin Other Names Ampicillin pivaloyloxymethyl ester, Pivaloylampicillin, Pivaloyloxymethyl ampicillinate, Pivampicilina, Pivampicillin, Pivampicilline, Pivampicillinum
Type
Formula C22H29N3O6S
Weight Average: 463.547
Monoisotopic: 463.177706365
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Pivaloylampicillin
Pivaloylampicillin

Uses

Pivaloylampicillin is an ampicillin prodrug used to treat a variety of infections.

or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.

Pivaloylampicillin is also used to associated treatment for these conditions: Susceptible Bacterial Infections

How Pivaloylampicillin works

Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Elimination Route

Absorbed following oral administration.

Half Life

Approximately 1 hour.

Innovators Monograph

You find simplified version here Pivaloylampicillin

*** Taking medicines without doctor's advice can cause long-term problems.
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