Pivampicillinum
Pivampicillinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Pivalate ester analog of ampicillin.
Pivampicillinum is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.
Trade Name | Pivampicillinum |
Generic | Pivampicillin |
Pivampicillin Other Names | Ampicillin pivaloyloxymethyl ester, Pivaloylampicillin, Pivaloyloxymethyl ampicillinate, Pivampicilina, Pivampicillin, Pivampicilline, Pivampicillinum |
Type | |
Formula | C22H29N3O6S |
Weight | Average: 463.547 Monoisotopic: 463.177706365 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Pivampicillinum is an ampicillin prodrug used to treat a variety of infections.
or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
Pivampicillinum is also used to associated treatment for these conditions: Susceptible Bacterial Infections
How Pivampicillinum works
Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Elimination Route
Absorbed following oral administration.
Half Life
Approximately 1 hour.
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