Plexel-s
Plexel-s Uses, Dosage, Side Effects, Food Interaction and all others data.
Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
After isovolemic exchange of blood with 500 mL of HES in healthy volunteers, blood volume is maintained for at least 6 hours
| Trade Name | Plexel-s |
| Generic | Hydroxyethyl Starch |
| Hydroxyethyl Starch Other Names | HAES, Hetastarch, Hydroxyethylstarch |
| Weight | 6%w/v |
| Type | Infusion |
| Protein binding | Data not found. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Searle Pakistan (pvt,) Ltd, |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Plexel-s is a plasma volume substitute used to treat and prevent hypovolemia.
An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
Plexel-s is also used to associated treatment for these conditions: Hypovolaemia, Granulocyte yield increase
How Plexel-s works
Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. Recent studies have indicated that HES may reduce capillary leakage.
Toxicity
LDF50 (IV, rabbit): 8460 mg/Kg.
Food Interaction
No interactions found.Volume of Distribution
5.9 L.
Elimination Route
Peak concentration (C(max), 4.34 mg/mL)
Half Life
Terminal half-life is 16.1 h. Elimination half-life is 12 h.
Clearance
31.4 mL/min
Elimination Route
Approximately 62 % of HES was excreted as hydroxyethyl starch molecules in urine within 72 hours.
Innovators Monograph
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