Positive Skin Test Control - Histamine
Positive Skin Test Control - Histamine Uses, Dosage, Side Effects, Food Interaction and all others data.
A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Positive Skin Test Control - Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
| Trade Name | Positive Skin Test Control - Histamine |
| Generic | Histamine |
| Histamine Other Names | 4-imidazoleethylamine, 5-imidazoleethylamine, beta-aminoethylglyoxaline, beta-aminoethylimidazole |
| Type | Injection |
| Formula | C5H9N3 |
| Weight | Average: 111.1451 Monoisotopic: 111.079647303 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Positive Skin Test Control - Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
Positive Skin Test Control - Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Positive Skin Test Control - Histamine is also used to associated treatment for these conditions: Migraine
How Positive Skin Test Control - Histamine works
Positive Skin Test Control - Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Positive Skin Test Control - Histamine has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Positive Skin Test Control - Histamine also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively.
Toxicity
LD50=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.
Food Interaction
No interactions found.Elimination Route
Readily absorbed after parenteral administration.
Innovators Monograph
You find simplified version here Positive Skin Test Control - Histamine
