Potassium Gluconate

Potassium Gluconate Uses, Dosage, Side Effects, Food Interaction and all others data.

Potassium Gluconate is a salt of Potassium cation and is classified as a food additive by the FDA . It is also used as a potassium supplement .

Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function .

In dietary supplements, potassium is often present as potassium chloride, but many other forms—including potassium citrate, phosphate, aspartate, bicarbonate, and gluconate—are also used . Potassium Gluconate is believed to be more palatable and non-acidifying than potassium chloride (KCl) .

Trade Name Potassium Gluconate
Generic Potassium gluconate
Potassium gluconate Other Names potassium D-gluconate, Potassium gluconate
Weight 550mg, 595mg
Type Oral tablet
Formula C6H11KO7
Weight Average: 234.245
Monoisotopic: 234.01418418
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Potassium Gluconate
Potassium Gluconate

Uses

Potassium Gluconate is a potassium supplement indicated in the treatment and prevention of hypokalemia.

Because of potassium’s wide-ranging roles in the body, low intakes can increase the risk of illness .

Potassium supplements are indicated to prevent hypokalemia in patients who would be at particular risk if hypokalemia were to develop (e.g., digitalis treated patients with significant cardiac arrhythmias). Potassium deficiency occurs when the rate of loss through renal excretion and/or loss from the gastrointestinal tract is higher than the rate of potassium intake. In addition to serving as a preventative supplement, potassium gluconate also serves as a treatment for decreased potassium levels , , .

Potassium Gluconate is also used to associated treatment for these conditions: Potassium deficiency

How Potassium Gluconate works

Potassium is the most abundant cation (approximately 150 to 160 mEq per liter) within human cells. Intracellular sodium content is relatively low. In the extracellular fluid, sodium predominates and the potassium content is low (3.5 to 5 mEq per liter). A membrane-bound enzyme, sodium-potassium–activated adenosinetriphosphatase (Na +K +ATPase), actively transports or pumps sodium out and potassium into cells to maintain the concentration gradients. The intracellular to extracellular potassium gradients are necessary for nerve impulse signaling in such specialized tissues as the heart, brain, and skeletal muscle, and for the maintenance of physiologic renal function and maintenance of acid-base balance. High intracellular potassium concentrations are necessary for numerous cellular metabolic processes .

Intracellular K+ serves as a reservoir to limit the fall in extracellular potassium concentrations occurring under pathologic conditions with loss of potassium from the body .

Toxicity

Acute oral toxicity (LD50): 9100 mg/kg in the mouse

Toxicity from overdose is rare but may result from intentional ingestion of potassium. Iatrogenic overdoses may occur .

Local irritation after ingestion causes GI upset. Severe hyperkalemia after large IV or oral overdoses causes muscular dysfunction including weakness, paralysis, cardiac dysrhythmias, and rarely death .

Mild to moderate toxicity

Nausea, vomiting, diarrhea, paresthesias, and muscle cramps are common. Rarely, gastrointestinal bleed may occur.

Severe toxicity

In severe toxicity, muscular weakness progressing to paralysis may occur. Cardiac arrhythmia often occur at concentrations greater than 8 mEq/L and death from cardiac arrest at concentrations of 9 to 12 mEq/L or higher. Characteristic ECG findings occur in the following order: peaked T waves, QRS complex blends into the T wave, PR interval prolongation, P wave is lost and ST segments depress, merging S and T waves, and finally, sine waves. The presence of the sine wave is a near terminal event, signaling that hemodynamic collapse and cardiac arrest are near. As serum hyperkalemia is corrected towards normal concentrations, the ECG changes resolve in reverse order .

Food Interaction

No interactions found.

Volume of Distribution

Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity .

Elimination Route

Potassium is rapidly and well absorbed. A 2016 dose-response trial found that humans absorb about 94% of potassium gluconate in supplements, and this absorption rate is similar to that of potassium from potatoes .

Clearance

Potassium is freely filtered by the glomerulus in the kidney. The majority of filtered potassium is reabsorbed in the proximal tubule and loop of Henle. Less than 10% of the filtered load reaches the distal nephron. In the proximal tubule of the nephron, potassium absorption is mainly passive and proportional to Na+ and water. K+ reabsorption in the thick ascending limb of Henle occurs through both transcellular and paracellular pathways. The transcellular component is regulated by potassium transport on the apical membrane Na+-K+-2Cl− cotransporter. The secretion of potassium begins in the early distal convoluted tubule of the nephron and progressively increases along the distal nephron into the cortical collecting duct. Most urinary K+ can be accounted for by electrogenic K+ secretion mediated by principal cells in the initial collecting duct and the cortical collecting duct. An electroneutral K+ and Cl− cotransport mechanism is also present on the apical surface of the distal nephron. Under conditions of potassium deficiency, reabsorption of the cation occurs in the collecting duct. This process is regulated by the upregulation in the apically located H+-K+-ATPase on α-intercalated cells .

Elimination Route

90% of potassium is eliminated via the kidneys. A small amount is eliminated in feces and sweat .

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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