Prilotekal Uses, Dosage, Side Effects and more
A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Prilotekal binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
| Trade Name | Prilotekal |
| Availability | Discontinued |
| Generic | Prilocaine |
| Prilocaine Other Names | Prilocain, Prilocaina, Prilocaïne, Prilocaine, Prilocaine base, Prilocainum, Propitocaine |
| Type | Injection |
| Formula | C13H20N2O |
| Weight | Average: 220.3107 Monoisotopic: 220.157563272 |
| Protein binding | 98% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Sintetica Limited |
| Available Country | United Kingdom, |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Prilotekal is a local anesthetic used in dental procedures.
Used as a local anaesthetic and is often used in dentistry.
Prilotekal is also used to associated treatment for these conditions: Local anesthesia therapy
How Prilotekal works
Prilotekal acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Food Interaction
- Take separate from meals. This is only required when prilocaine is used in the mouth, as it may cause numbness, which can cause bite injury when eating.
Drug Interaction
Major: sulfamethoxazole / trimethoprimUnknown: acetaminophen, aspirin, charcoal, epinephrine, naproxen, alpha-lipoic acid, diphenhydramine, loratadine, dextromethorphan, guaifenesin, atorvastatin, metoprolol, acetaminophen / hydrocodone, acetaminophen, clopidogrel, infliximab, cyanocobalamin, cholecalciferol, cetirizine
Disease Interaction
Major: methemoglobinemiaModerate: renal/hepatic dysfunction
Elimination Route
Prilotekal is metabolized in both the liver and the kidney and excreted via the kidney.
