Prilocaine

Prilocaine Uses, Dosage, Side Effects, Food Interaction and all others data.

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.

Trade Name Prilocaine
Availability Discontinued
Generic Prilocaine
Prilocaine Other Names Prilocain, Prilocaina, Prilocaïne, Prilocaine, Prilocaine base, Prilocainum, Propitocaine
Type Injection
Formula C13H20N2O
Weight Average: 220.3107
Monoisotopic: 220.157563272
Protein binding

98%

Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Prilocaine
Prilocaine

Uses

Prilocaine is a local anesthetic used in dental procedures.

Used as a local anaesthetic and is often used in dentistry.

Prilocaine is also used to associated treatment for these conditions: Local anesthesia therapy

How Prilocaine works

Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Food Interaction

  • Take separate from meals. This is only required when prilocaine is used in the mouth, as it may cause numbness, which can cause bite injury when eating.

Elimination Route

Prilocaine is metabolized in both the liver and the kidney and excreted via the kidney.

Innovators Monograph

You find simplified version here Prilocaine

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http://www.hmdb.ca/metabolites/HMDB0014888
http://www.genome.jp/dbget-bin/www_bget?drug:D00553
http://www.genome.jp/dbget-bin/www_bget?cpd:C07531
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4906
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505066
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http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225477
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8686
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8404
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1194
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000511
http://www.pharmgkb.org/drug/PA451101
https://en.wikipedia.org/wiki/Prilocaine
*** Taking medicines without doctor's advice can cause long-term problems.
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